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In some embodiments, the pharmaceutical formulations or compositions described herein are stable with respect to pH over a period of any of at least about 1 day, at least about 2 days, at least about 3 days, at least about 4 days, at least about 5 days, at least about 6 days, at least about 1 week, at least about 2 weeks, at least about 3 weeks, at least about 4 weeks, at least about 5 weeks, at least about 6 weeks, at least about 7 weeks, at least about 8 weeks, at least about 1 month, at least about 2 months, at least about 3 months, at least about 4 months, at least about 5 months, or at least about 6 months

PRMT5 is a critical regulator of breast cancer stem cell function via histone methylation and FOXP1 expression

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For doses requiring split injections (15 mg for 10mg/30mg vials, 20 mg for 50mg vial), space injections at least 2 inches apart on different body regions